Major and minor grooves of DNA. Minor groove is a binding site for the dye Hoechst 33258. Twin helical strands form the DNA backbone. Another double helix may be found by tracing the spaces, or grooves, between the strands. These voids are adjacent to the base pairs and may provide a binding site.. The major and minor grooves are very important for protein binding to DNA, but we will not be discussing this more specifically. Figure 12.1.4 12.1. 4: DNA has (a) a double helix structure and (b) phosphodiester bonds. The (c) major and minor grooves are binding sites for DNA binding proteins during processes such as transcription (the copying.

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DNA Double helix 2.2.2 Major groove and minor groove. The double helix is a quite rigid and viscous molecule of an immense length and a small diameter. It presents a major groove and a minor groove. The major groove is deep and wide, the minor groove is narrow and shallow.. My teaching project page: Biochemistry Literacy for Kidshttps://www.biochemistryliteracyforkids.com/Proteins and other molecules that bind DNA specifically r.